After the defeat of the demon lord Hadlar all of the monsters were unleashed from his evil will and moved to the island of Delmurin to live in peace. Dai is the only human living on the island. Having been raised by the kindly monster Brass, Dai's dream is to grow up to be a hero. He gets to become one when Hadlar is resurrected and the previous hero, Avan, comes to train Dai to help in the battle. But Hadlar, announcing that he now works for an even more powerful demon lord, comes to kill Avan. To save his students Avan uses a Self-Sacrifice spell to attack, but is unable to defeat Hadlar. When it seems that Dai and Avan's other student Pop are doomed a mark appears on Dai's forehead and he suddenly gains super powers and is able to fend off Hadlar. The two students then go off on a journey to avenge Avan and bring peace back to the world.
(Source: ANN)

It's the Century of Darkness where monsters known as Vandels rule the world, and the Vandel Busters are the only ones who can fight them. When a group of Busters are killed in battle, they pass on their magic Saiga weapons to Beet, making him the strongest Buster ever. But Beet won't just fight the Vandels--he wants to destroy them and finally end the Century of Darkness.
(Source: Viz)

In this world, there are some evil creatures known as "chousha" (the kanji read "Chou" = "Omen" and "Sha" = "person") that can only be killed by Cremators, people who use fire to incinerate them.

(Source: Batoto)