FLCL

From Tokyopop:
Naota's life isn't simple: he lives with his eccentric father and grandfather in a two-story house above a family-owned bakery in a town marked by a gigantic factory at its heart. The factory looks suspiciously like a hand iron, replete with a steam release at the top--not the most typical landmark. Life is already strange enough, but to top it off, his older brother's ex-girlfriend starts making extremely suggestive passes at him...and an impish, playful alien smacks him in the head with a bass guitar and then infuses herself into his family.