A slice of life story in high school. How childhood friends like Hei and Banri will grow up among other good friends......how they help pulling their problematic friends from misery......this is one of the best slice of life story you will have ever seen!

The time is the Italian Renaissance. The setting is Venice. 21 year old Legare Salviatti lives with his father Georg, a seemingly simple medicine man who years ago separated from his wife and moved from Florence. Legare spends his days idly dabbling in painting, music, and flirting with women when not pursuing his one true passion, alchemy. However, his peaceful life is suddenly turned upside down when his father is arrested on suspicion of practicing black magic. Desperate to save his father's life, Legare turns to a priest for help, but nothing is as it seems in the twisted world of politics...

In the year 2000, a Chinese nuclear experiment went wrong mid-transit, resulting in Japan falling into ruin. Those that survived were housed in Japanese based American military facilities to escape from the deadly radiation and learned to live following regimented lives of labor and learning.
To relieve the boredom, a recreational drug called "Zero" was created and sold illegally. Taking the drug induced a dream filled sleep where people saw their lives as they were in the year 2000. And in the cases of those who hadn't been born before 2000? The most they could surmise is that they saw who they were in their past lives.
But it seems there's something is brewing below the surface and those past lives may just hold the answer.