Hark! The city is in peril! Who you gonna call? Colors!Sacchan, Yui and Kotoha are here to protect the city, solving mysteries and battling enemies with help from their friends.But their quest isn't an easy one as their arch-nemesis Saitou, the violent police officer of Ueno, meets them at every turn.

Hitori Bocchi suffers from extreme social anxiety, she’s not good at talking to people, takes pretty extreme actions, is surprisingly adept at avoiding people, her legs cramp when she overexerts herself, gets full of herself when alone, will vomit when exposed to extreme tension and often comes up with plans. Now she is entering middle school and her only friend, Yawara Kai, is attending a different school. This leaves Bocchi alone, surrounded by new classmates with whom she must make friends before Kai will talk to her again.

To sell 10 million copies! This is the dream of the newbie editor, Sakurai Tamako. As she goes through funny moments, sad times, and even hardships, Tamako is running towards her dream!