Escaflowne, the God Protector of Fanelia, has been stolen and the country is left in ruins. Desperate to find the key to Escaflowne's seal and recover the legendary guymelef, Van Fanel, Prince of Fanelia is sent to Earth, only to find it in the possession of a high school girl, Hitomi Hoshino. With enemies chasing them at every turn, can the two reclaim what was lost?

Named Messiah Knight when serializing in Monthly Asuka Fantasy DX, but renamed to HITOMI when tankoubon were published.

12.000 years after the events of Sousei no Aquarion, mankind is threatened by a new enemy from other dimension labeled "Abductors", who just like the Shadow Angels, invade the human cities to kidnap its inhabitants. To defend humanity from this invasion, the Neo-DEAVA organization establish two teams, one composed of only males and other of only females, each one piloting their own giant machines called "Aquaria". To protect his new friend Mikono, teenager Amata Sora decided to use the powers he has kept secret his entire life and by combining Vectors with male and female pilots into one single robot, the legendary giant Aquarion is reborn once more.
(Source: MU)

In the near future on the starship Galaxy, Sheryl Nome lived with her parents Abel and Sally. The government tracked her parents down who were rebelling against mandatory human enhancing implants and Sheryl was the only one who got away alive. Barely surviving on her own on the streets, Grace O’Connor, a manager at a talent agency brings her in to make her a star. Several years later Sheryl is enrolled into the Erato Music School where she meets Amagi Lilies, a brilliant singer and they become friends. However, tragedy strikes and Lilies dies trying to save Sheryl. To make sure her parent’s sacrifice was not in vain and to keep her promise with Lilies, Sheryl enters into the entertainment world to become the greatest singer in the universe.
(Source: MangaHelpers)