From Broccoli:
Breaking the Rules in the Game of Love! When you're a cupid in training, you gotta play by the rules: No socializing with your targets. Don't consort with the enemy. Practice archery every day. Maybe if someone had told Koi, Ai, and Ren, they could stay out of trouble. The girls try to finish their missions by the book, but something always gets in the way.

A guy named Al goes around killing "rebel dolls", which were used as fighting machines in the war before, but their neglect over the years has made them become "rebels''. One day while trying to look for some, a boy comes falling out of the sky in hand cuffs, and following him is some rebel dolls. This is a prize catch for a doll hunter, but why are they after the boy? And is that boy even human??

With Mew Ichigo studying abroad in London, the remaining four girls from Cafe Mew Mew are one too few. Luckily, a new Mew is about to emerge. Berry just transferred to a different junior high because she thought their school outfits were cute. Little does she know she's about to become the first Mew Mew with TWO sets of animal genes in her blood. Half cat, half rabbit, she's joining the Mew Mew team just in time. A new gang calling itself the Crusaders has appeared, and its leader just happens to love wild game like rabbit - well done and served for his dinner! When Mew Ichigo returns from London she's going to be very, very surprised!
(Source: Tokyopop)

In the story it is revealed that when Ichigo Momomiya, the protagonist from the original Tokyo Mew Mew, is studying in England with Masaya Aoyama, Berry Shirayuki is introduced. Berry is trying to adjust to the private school which she has just transferred to. She later runs into Ryou Shirogane, who she follows into Café Mew Mew. While Berry is staring in awe at the cakes and pastries, Ryou sees her and yells, wondering who she is. Berry, caught by surprise, falls on top of the snacks. Embarrassed, she runs with her eyes closed into the employee's only section of the Café, and runs into the DNA-infusion device. She is transformed into a Mew Mew, with the DNA of a rabbit and a cat. She must temporarily take Ichigo's place as leader of the Mews to defend Tokyo from the Saint Rose Crusaders, while juggling her schoolwork and her new job at the Café. When Ichigo returns, she and Berry quickly become friends and she and the other Mew Mews move to her school in case of an attack